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Related Concept Videos

Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
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Related Experiment Video

Updated: May 20, 2026

Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells
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Published on: September 18, 2016

Immunoinflammation and functional gastrointestinal disorders.

Ming-Kai Chen1, Shu-Zhong Liu, Li Zhang

  • 1Department of Gastroenterology, RenMin Hospital of WuHan University, HuBei Province, China. kaimingchen@163.com

Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association
|July 25, 2012
PubMed
Summary

Functional gastrointestinal disorders (FGIDs) involve GI tract dysfunction. Emerging research highlights the significant role of cytokines and immunoinflammation in FGID development and symptoms.

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Area of Science:

  • Gastroenterology
  • Immunology
  • Pathophysiology

Background:

  • Functional gastrointestinal disorders (FGIDs) are complex conditions affecting the GI tract.
  • Pathogenesis theories include abnormal GI motility, visceral hypersensitivity, and psychomental factors.
  • The influence of cytokines on GI function is increasingly recognized.

Purpose of the Study:

  • To explore the intricate relationship between immunoinflammation and FGIDs.
  • To provide an overview of current research on cytokines' role in FGIDs.

Main Methods:

  • Literature review of recent studies on immunoinflammation and FGIDs.
  • Analysis of the impact of cytokines on GI motility and FGID symptoms.

Main Results:

  • Cytokines significantly influence gastrointestinal motility.
  • Immunoinflammatory processes are implicated in the pathophysiology of FGIDs.
  • Growing evidence links cytokine activity to FGID symptoms.

Conclusions:

  • Immunoinflammation is a key factor in understanding FGIDs.
  • Further research into cytokine pathways may reveal novel therapeutic targets for FGIDs.