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Trophic effect of granulocyte-macrophage colony-stimulating factor on central cholinergic neurons in vitro
M Kamegai1, Y Konishi, T Tabira
1Division of Demyelinating Disease and Aging, National Institute of Neuroscience, NCNP, Tokyo, Japan.
Brain Research
|November 5, 1990
Abstract:
Granulocyte-macrophage colony-stimulating factor (GM-CSF) elevated choline acetyltransferase (ChAT) activities of mouse septal neurons as well as of cholinergic hybridoma line cells SN6.10.2.2 in vitro. It augmented ChAT activities and neurite extension of interleukin 3-activated cholinergic neurons. Thus, GM-CSF should be added as a trophic factor for central cholinergic neurons.