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Related Experiment Video

Updated: May 20, 2026

A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases

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Falsely elevated testosterone due to heterophile antibodies.

Irene Cheng¹, John M Norian, John D Jacobson

¹From the Section of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics, Loma University School of Medicine, Loma Linda, California.

Obstetrics and Gynecology

|July 25, 2012

Summary

Heterophile antibodies can cause falsely elevated testosterone levels in asymptomatic patients. Liquid chromatography-mass spectrometry can confirm true hormone levels, avoiding unnecessary treatments.

Area of Science:

Endocrinology
Clinical Chemistry
Immunology

Background:

Falsely elevated testosterone is a rare clinical finding.
Heterophile antibodies are a known cause of such interferences.

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Mismanagement can lead to unnecessary diagnostic procedures or therapies.