Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Introduction to Innate and Adaptive Immunity01:21

Introduction to Innate and Adaptive Immunity

The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Large distant deletion disrupts CDKN2A enhancer and predisposes to melanoma.

medRxiv : the preprint server for health sciences·2026
Same author

Sustained clinical remission and relapse of severe eosinophilic asthma following long-term mepolizumab treatment.

Allergology international : official journal of the Japanese Society of Allergology·2026
Same author

20th Anniversary of human-induced pluripotent stem cells and the role of microscopy.

Journal of microscopy·2026
Same author

GWAS meta-analysis provides new insights into uveal melanoma risk.

British journal of cancer·2026
Same author

A Real-World Controlled Multicentre Study Evaluating the Association Between Benralizumab Therapy and Major Outcomes in Severe Asthma.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026
Same author

Genetic architecture of multiple primary cutaneous melanoma in the absence of high-penetrance susceptibility genes.

The Journal of investigative dermatology·2026

Related Experiment Video

Updated: May 20, 2026

Intra-tracheal Administration of Haemophilus influenzae in Mouse Models to Study Airway Inflammation
09:56

Intra-tracheal Administration of Haemophilus influenzae in Mouse Models to Study Airway Inflammation

Published on: March 2, 2016

Innate interferons inhibit allergen and microbial specific T(H)2 responses.

Antonia L Pritchard1, Olivia J White, Julie G Burel

  • 1Lung and Allergy Research Centre, School of Medicine, The University of Queensland, Princess Alexandra Hospital, Buranda, Brisbane, Australia. a.pritchard2@uq.edu.au

Immunology and Cell Biology
|July 25, 2012
PubMed
Summary

Interferon-beta (IFN-β) effectively suppressed allergic and antigen-specific T(H)2 cytokine responses in human cells. This finding highlights IFN-β

More Related Videos

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
10:00

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

Published on: March 24, 2015

Related Experiment Videos

Last Updated: May 20, 2026

Intra-tracheal Administration of Haemophilus influenzae in Mouse Models to Study Airway Inflammation
09:56

Intra-tracheal Administration of Haemophilus influenzae in Mouse Models to Study Airway Inflammation

Published on: March 2, 2016

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
10:00

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

Published on: March 24, 2015

Area of Science:

  • Immunology
  • Molecular Biology
  • Allergy Research

Background:

  • Innate interferons (IFNs) are known to regulate T(H)2 cytokine production.
  • Previous research has not investigated IFN's role in attenuating T(H)2 responses to specific allergens or antigens.

Purpose of the Study:

  • To investigate the abrogation of allergen- and antigen-stimulated T(H)2 responses by IFN-β and IFN-λ.
  • To analyze the impact of these interferons on cytokine production and gene expression in sensitized individuals.

Main Methods:

  • Peripheral blood mononuclear cells (PBMCs) from 12 sensitized individuals were cultured with stimuli (HDM, RV, influenza vaccine, TT) and either IFN-β or IFN-λ.
  • Interferon-gamma (IFN-γ), IL-5, and IL-13 protein levels were measured using ELISA.
  • Quantitative PCR (qPCR) assessed gene expression related to T(H)2 cytokine control.

Main Results:

  • IFN-β consistently abrogated T(H)2 responses to house dust mite (HDM) and influenza.
  • IFN-β also attenuated responses to rhinovirus (RV) and tetanus toxoid (TT) by day 5.
  • IFN-λ showed limited and inconsistent effects on T(H)2 production, with a notable decrease in IL-5 only with RV.
  • Differential regulation of GATA3 and SOCS3 mRNA was observed with IFN-β stimulation.

Conclusions:

  • IFN-β demonstrated a potent and consistent ability to abrogate T(H)2 cytokine production against diverse allergens and antigens.
  • IFN-λ exhibited minimal impact on T(H)2 responses.
  • These findings suggest a significant role for IFN-β in controlling T(H)2-mediated immune responses.