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Updated: May 20, 2026
08:48
Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
Published on: January 29, 2016
The benefits of exercise training in multiple sclerosis
Robert W Motl1, Lara A Pilutti
1Department of Kinesiology and Community Health, University of Illinois, Urbana-Champaign, 233 Freer Hall, Urbana, IL 61801, USA. robmotl@illinois.edu
Nature Reviews. Neurology
|July 25, 2012
Summary
Exercise training shows promise for improving multiple sclerosis (MS) symptoms, including walking, fatigue, and quality of life. Further research is needed to fully understand its impact on inflammation and neurodegeneration in MS patients.
Area of Science:
- Neurology
- Rehabilitation Medicine
- Immunology
Background:
- Multiple sclerosis (MS) is an immune-mediated central nervous system (CNS) disease causing demyelination and neurodegeneration.
- MS-related damage impacts bodily functions, affecting patient activities like walking and participation.
- The International Classification of Functioning, Disability and Health (ICF) model frames MS pathogenesis and consequences.
Purpose of the Study:
- To review evidence on the effects of exercise training in individuals with MS.
- To assess the potential of exercise to improve outcomes within the ICF framework.
- To highlight current research limitations and future directions.
Main Methods:
- Review of clinical trial evidence regarding exercise training in MS.
- Analysis of exercise effects on ICF-related components such as function, activity, and participation.
- Discussion of proposed mechanisms of exercise on inflammation and neurodegeneration.
Main Results:
- Exercise training demonstrates beneficial effects on muscle strength, aerobic capacity, and walking performance in MS.
- Improvements observed in fatigue, gait, balance, and overall quality of life.
- Preliminary evidence suggests potential benefits for depression and cognition, though research is limited.
Conclusions:
- Exercise training offers a promising non-pharmacological intervention for managing multiple sclerosis.
- Exercise may positively influence key aspects of functioning and disability in MS patients.
- Further research is essential to elucidate mechanisms and optimize exercise interventions for MS.
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