Do overweight patients have a better five years prognosis after an acute myocardial infarction treated with coronary intervention?
Related Experiment Video
Updated: May 20, 2026
Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
Published on: April 17, 2021
Anna Tomaszuk-Kazberuk1, Marcin Kożuch, Jolanta Małyszko
1Department of Cardiology, Medical University in Bialystok, Poland. walkaz@poczta.fm
Insights
Higher body mass index (BMI) is associated with better long-term survival after ST-segment elevation myocardial infarction (STEMI) treated with primary angioplasty. This survival benefit for patients with BMI ≥ 25 kg/m² emerges after one year.
Area of Science:
- Cardiology
- Internal Medicine
- Public Health
Background:
- Overweight and obesity may offer a survival advantage post-myocardial infarction (MI), irrespective of age or treatment.
- Understanding the impact of body composition on cardiovascular outcomes is crucial.
Purpose of the Study:
- To investigate the relationship between body mass index (BMI) and long-term mortality in patients with ST-segment elevation myocardial infarction (STEMI).
- To assess the influence of BMI on outcomes following primary percutaneous coronary intervention (PCI).
Main Methods:
- A prospective study of 131 STEMI patients achieving TIMI 3 flow post-primary PCI.
- Patients were categorized into two groups: BMI < 25 kg/m² (underweight/normal) and BMI ≥ 25 kg/m² (overweight/obese).
- Five-year mortality rates were compared between the two BMI groups.
Main Results:
- Overall, 14.5% of patients died within five years.
- Patients with BMI ≥ 25 kg/m² exhibited significantly lower five-year mortality (10%) compared to those with BMI < 25 kg/m² (30%) (p < 0.001).
- No significant differences in 30-day or one-year mortality were observed between groups.
Conclusions:
- Patients with STEMI treated with primary PCI and a BMI ≥ 25 kg/m² demonstrate a better five-year survival prognosis.
- This improved long-term survival associated with higher BMI is independent of other confounding factors.
- Short-term mortality (30-day and one-year) does not differ significantly based on BMI in this patient cohort.
Background:
Obesity and overweight alone may confer a survival benefit after myocardial infarction, independent of age, medical care or therapy.
Aim:
To evaluate the impact of body mass index (BMI) on long-term mortality in ST-segment elevation acute myocardial infarction (STEMI) patients treated by primary angioplasty (PCI).
Methods:
We prospectively studied a homogenous group of 131 patients who had suffered STEMI, and subsequently exhibited a TIMI 3 flow after primary PCI. The patients (41 women, 90 men, mean age 58.3 ± 10.8 years) were analysed in two groups: Group 1 - 30 (23%) patients with BMI 〈 25 kg/m(2) and Group 2 - 101 (77%) patients with BMI ≥ 25 kg/m(2).
Results:
Altogether, 19 (14.5%) patients died during the five-year follow-up period - nine out of 30 (30%) were patients with BMI 〈 25 kg/m(2), and ten out of 101 (10%) were patients with BMI ≥ 25 kg/m(2) (p 〈 0.001). Individuals with BMI ≥ 25 kg/m(2) had lower five-year mortality, and this was independent of other potentially confounding variables. Area under the receiver-operating characteristic (ROC) curves for death with respect to weight on ROC analysis was significantly different than for a random model (p 〈 0.05). There were no significant differences in 30-day mortality and one-year mortality (p = 0.6517 and p = 0.3573, respectively).
Conclusions:
Patients after primary angioplasty for STEMI with BMI 〈 25 kg/m(2) and patients with BMI ≥ 25 kg/m(2) have no difference in 30-day or one-year mortality, but individuals with BMI ≥ 25 kg/m(2) have a better five year prognosis, and this is independent of other potentially confounding variables.
Related Concept Videos
01:28Acute Coronary Syndrome IV: Interprofessional Care
01:27Coronary Artery Disease V: Interprofessional Care
01:26Angina IV: Management
01:20Exercise and Cardiovascular Response
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
01:20Angina V: Nursing Management
01:29Cardiomyopathy V: Interprofessional Care