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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
Drug repurposing: far beyond new targets for old drugs
1Translational Informatics Division, Department of Internal Medicine, University of New Mexico School of Medicine, MSC10 5550, 1 University of New Mexico, Albuquerque, New Mexico 87131-0001, USA. toprea@salud.unm.edu
The AAPS Journal
|July 25, 2012
Summary
Drug repurposing identifies new uses for existing medications, leveraging prior research and safety data. This strategy addresses knowledge gaps and offers viable therapeutic options by considering efficacy, side effects, and intellectual property.
Area of Science:
- Pharmacology
- Drug Discovery
- Translational Medicine
Background:
- Drug repurposing is a valuable strategy for identifying novel medicines.
- It capitalizes on prior investments and de-risks clinical development.
- Significant gaps persist in understanding drug-target interactions and accumulating clinical data.
Purpose of the Study:
- To explore the multifaceted considerations for successful drug repurposing.
- To highlight the importance of data availability and intellectual property in identifying new therapeutic indications.
Main Methods:
- Analysis of existing drug data, including safety and efficacy profiles.
- Evaluation of drug-target interactions and their relevance to disease.
- Assessment of the intellectual property landscape and commercial feasibility.
Main Results:
- Publicly available drug data can reveal repurposing opportunities.
- Differences in side effect tolerance influence the feasibility of certain applications.
- Relevance to the disease and intellectual property are critical factors.
Conclusions:
- Drug repurposing extends beyond identifying new targets for old drugs.
- A comprehensive assessment of clinical, commercial, and intellectual property factors is essential.
- This approach offers a pragmatic pathway to novel therapeutics.
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