Related Experiment Video
Updated: May 20, 2026

Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents
Published on: September 10, 2018
Multiple tests of cost-effectiveness angles
1Department of Mathematics, University of Bremen, Germany. georg.gutjahr@math.uni-bremen.de
Abstract:
Cost-effectiveness angles are an attractive measure of performance when comparing effects and costs of health-care therapies because they have a clear interpretation and are well suited for statistical inference. In clinical trials, a common setup is the comparison of multiple new therapies with a single control. If cost-effectiveness angles are calculated for each comparison, multiplicity issues should be taken into account when quantifying uncertainty of the point estimates. Therefore, this paper proposes a parametric test for multiple cost-effectiveness angles that guarantees strong family-wise error rate control. The idea is to replace the test of m cost-effectiveness angles as a union-intersection test of 3m linear hypotheses. Considering the correlation structure of the individual test statistics for the linear hypotheses leads to a maximum-type test for the intersection hypothesis. Inverting these test decisions then gives simultaneous CIs of cost-effectiveness angles with the appropriate coverage probabilities.
More Related Videos
08:36The Adjuvant Efficacy of Angong Niuhuang Pill in the Treatment of Viral Encephalitis: A Meta-Analysis of Randomized Controlled Trials
Published on: April 19, 2024
06:16Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
Published on: August 9, 2024
Related Concept Videos
Multiple Comparison Tests
It would be easy to compare two samples using a significance alpha level of 0.05. In other words, there is only one sample pair to be compared. However, it would be difficult to identify a significantly different sample if the number...
Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Methods of Medium Optimization
Bonferroni Test
The means of different samples are first paired in all possible combinations.
The null hypothesis of the...
Cochran's Q Test