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Bioactive TiO2 fiber films prepared by electrospinning method.
1Engineering Research Center in Biomaterials, Sichuan University, Chengdu 610064, China.
Journal of Biomedical Materials Research. Part A
|July 25, 2012
Summary
Electrospinning creates bioactive titanium dioxide (TiO2) fiber films with tunable structures. Controlling fiber diameter, phase composition, and morphology optimizes apatite formation and osteoblast compatibility for enhanced bioactivity.
Area of Science:
- Biomaterials Science
- Materials Engineering
- Nanotechnology
Background:
- Developing bioactive materials is crucial for bone tissue engineering.
- Titanium dioxide (TiO2) exhibits promising biocompatibility and bioactivity.
- Controlling the nanostructure of TiO2 materials can enhance their biological performance.
Purpose of the Study:
- To prepare bioactive TiO2 fiber films using electrospinning.
- To investigate the influence of structural parameters on TiO2 fiber bioactivity.
- To optimize TiO2 fiber film properties for improved apatite formation and cell proliferation.
Main Methods:
- Electrospinning of a precursor solution (acetic acid/ethanol/tetrabutyl titanate/polyvinylpyrrolidone).
- Control of TiO2 fiber structure via feeding rate, PVP concentration, and sintering temperature.
- Assessment of bioactivity through simulated body fluid soaking and MG63 cell culture experiments.
- Analysis using X-ray diffraction and MTT assay.
Main Results:
- Anatase phase TiO2 fibers demonstrated superior early-stage apatite formation.
- Anatase-rutile TiO2 fibers supported better MG63 cell proliferation compared to other samples.
- TiO2 fibers with a diameter of 200 nm exhibited optimal apatite formation and osteoblast compatibility.
- Fiber structure, including the presence of string beads and diameter, significantly impacted bioactivity.
Conclusions:
- Electrospinning is an effective method for producing bioactive TiO2 fiber films.
- Tailoring TiO2 fiber structure during electrospinning allows for optimization of bioactivity.
- The prepared TiO2 fiber films show potential for bone regeneration applications.
