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Optimal design of multi-arm multi-stage trials

James M S Wason1, Thomas Jaki

  • 1Hub for Trials Methodology Research, MRC Biostatistics Unit, Cambridge, UK. james.wason@mrc-bsu.cam.ac.uk

Statistics in Medicine
|July 25, 2012
PubMed
Summary

Multi-arm multi-stage (MAMS) trials improve drug development efficiency. This study proposes a new method for optimal MAMS trial design, minimizing sample size while maintaining statistical power and error rates.

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