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Updated: May 20, 2026
Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
Published on: March 11, 2021
Monte Carlo mitochondrial dosimetry and microdosimetry of 131I
Tomás A Carrillo-Cázares1, Eugenio Torres-García
1Laboratorio de Simulación Monte Carlo, Coordinación de Posgrado, Facultad de Medicina, Universidad Autónoma del Estado de México, Paseo Tollocan s/n, esquina Jesús Carranza, Colonia Moderna de la Cruz, Toluca, Estado de México, México.
Abstract:
A mitochondrion is an organelle found in most eukaryotic cells, which produces most of the energy needed by a living cell. It has been shown that ionising radiation causes mitochondrial damage leading to apoptosis or cell death. The aim of this work was to calculate, by Monte Carlo simulation, the specific energy (z) into the mitochondria, due to Auger electrons, conversion electrons and beta emission from (131)I, where the radionuclide was carried by a vector to the cell surface and the surrounding environment. A concentric spherical geometry represents a cell and its nucleus. Three different volumes were used to represent the mitochondria; they were placed in random positions within the cytoplasm. The z produced by a single event is due to low-energy electrons (76 %) and beta particles (24 %) and the mitochondria receive a total mean z two orders of magnitude higher than that of the cell nucleus.
