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Romiplostim as early treatment of immune thrombocytopenia with severe immunodeficiency

Francesca Palandri1, Nicola Polverelli, Francesca Lifrieri

  • 1Department of Hematology and Oncology L. e A. Seràgnoli, St. Orsola-Malpighi Hospital, University of Bologna;

Hematology Reports
|July 25, 2012
PubMed

Immunosuppressive agents are the standard therapeutic approach for immune thrombocy-topenia (ITP). Their prolonged use may increase the risk of infectious complications, particularly when the patient is already at higher infectious risk. In this setting, the use of drugs with a mechanism of action alternative to immunosuppression, like thrombopoietin receptor agonists (TRAs), may find particular indication. We report the unique case of a patient with severe immunodeficiency and ITP, who experienced a serious infectious complication while on steroids treatment, and who was successfully treated with Romiplostim second-line. The present experience supports the effectiveness and safety of TRAs as early treatment of ITP patients with drug-induced immunodeficiency or with active infections.

Keywords:
TPO receptor agonistimmune thrombocytopeniaimmunodeficiency.romi-plostim

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