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Radiosurgery for high-grade glioma
Emanuela Binello1, Sheryl Green, Isabelle M Germano
1Department of Neurosurgery, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, New York, NY 10129, USA.
Surgical Neurology International
|July 25, 2012
Summary
Stereotactic radiosurgery (SRS) may offer survival benefits for high-grade glioma (HGG) patients, particularly those with recurrent tumors. However, its role in newly diagnosed HGG and potential complications require further investigation.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Oncology
Background:
- Standard treatment for newly diagnosed high-grade gliomas (HGG) includes surgery, temozolomide (TMZ), and radiation therapy (XRT).
- No standard treatment exists for recurrent HGG.
- Stereotactic radiosurgery (SRS) delivers focused radiation, but its role in HGG management is unclear.
Purpose of the Study:
- To evaluate the role and survival benefit of stereotactic radiosurgery (SRS) in the management of newly diagnosed and recurrent high-grade gliomas (HGG).
Main Methods:
- Systematic literature search of the PubMed database.
- Exclusion of case reports and small case series.
- Analysis focused on overall median survival for newly diagnosed and recurrent HGG.
Main Results:
- SRS boost before XRT shows no survival benefit for newly diagnosed HGG.
- Retrospective data suggest potential survival benefit for SRS after XRT in newly diagnosed HGG.
- SRS may benefit recurrent HGG patients, but with higher complication risks; combination with targeted agents is under investigation.
Conclusions:
- Stereotactic radiosurgery (SRS) shows potential for improving survival in high-grade glioma (HGG) patients.
- Further controlled clinical trials are necessary to define SRS's optimal role in HGG management.
- Research is needed to clarify SRS benefits and risks in both newly diagnosed and recurrent HGG.
