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Pericytes and the blood-brain barrier: recent advances and implications for the delivery of CNS therapy

Annika Armulik, Maarja Mäe, Christer Betsholtz

    Therapeutic Delivery
    |July 25, 2012
    PubMed

    Abstract:

    "Once the regulation of brain endothelial transcytosis is understood at the molecular level, it should be possible to exploit these mechanisms as targets for facilitated CNS drug delivery".

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    Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...

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