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Related Experiment Videos

Polymorphonuclear elastase in neonatal sepsis.

T Tsaka1, K R Herkner

  • 1Ludwig Boltzmann Institute for Paediatric Endokrinology, Vienna, Austria.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|December 14, 1990
PubMed
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Polymorphonuclear elastase (PMN-elastase) levels are significantly elevated in newborns with sepsis. Measuring PMN-elastase is a sensitive indicator for detecting and monitoring systemic infections in neonates.

Area of Science:

  • Biochemistry
  • Neonatal Medicine
  • Infectious Diseases

Background:

  • Neonatal sepsis is a critical condition requiring early diagnosis.
  • Polymorphonuclear elastase (PMN-elastase) is an enzyme released during neutrophil activation, a key component of the inflammatory response to infection.

Purpose of the Study:

  • To evaluate the diagnostic utility of plasma PMN-elastase levels in detecting systemic infections in newborn infants.
  • To assess the correlation between PMN-elastase activity and the clinical status of neonates during infection and recovery.

Main Methods:

  • Quantitative analysis of plasma PMN-elastase activity was performed in 135 newborn infants within the first 28 days of life.
  • Comparison of PMN-elastase levels between neonates with and without septicaemia.

Related Experiment Videos

  • Monitoring of PMN-elastase levels during the course of illness and recovery.

    • Main Results:

    • Significantly elevated PMN-elastase activity (75-700 µg/l) was observed in 15 neonates with septicaemia at the time of infection diagnosis (P < 0.0001).
    • A cut-off level of 65 µg/l was identified.
    • PMN-elastase levels normalized only upon confirmed patient recovery.

    Conclusions:

    • Plasma PMN-elastase determination is a sensitive biomarker for systemic infection in neonatology.
    • PMN-elastase levels serve as a valuable parameter for monitoring disease progression and clinical condition in neonates.