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Novel dry powder inhaler particle-dispersion systems
Martin J Donovan1, Aileen Gibbons, Matthew J Herpin
1Division of Pharmaceutics, College of Pharmacy, The University of Texas, 2409 University Avenue, PHR 4.214, Austin, TX 78712, USA.
Therapeutic Delivery
|July 25, 2012
Summary
Dry powder inhalers (DPIs) are rapidly advancing respiratory therapeutics. This review explores DPI designs, dispersion dynamics, and future trends, considering technical, regulatory, and market forces for effective lung delivery.
Area of Science:
- Respiratory therapeutics
- Drug delivery devices
Background:
- Dry powder inhalers (DPIs) are a growing area in respiratory therapeutics.
- Effective dispersion and reproducible delivery from DPIs require overcoming significant inter-particulate forces.
Purpose of the Study:
- To review the proliferation of DPIs and the underlying principles of powder dispersion.
- To survey existing and novel DPI designs, categorizing them as passive or active.
- To link device design features to powder dispersion dynamics and future trends.
Main Methods:
- Literature review of marketed and developmental DPIs.
- Analysis of inter-particulate forces relevant to powder dispersion.
- Discussion of device-driven and patient-driven mechanisms for improved DPI performance.
Main Results:
- A wide diversity of DPI designs exists, driven by the need for efficient powder dispersion.
- Both passive and active DPI designs are under development to enhance drug delivery.
- Understanding powder dispersion dynamics is key to optimizing DPI performance.
Conclusions:
- The future of DPIs involves a wide range of designs and mechanisms.
- Technical, regulatory, and market forces will shape the evolution of DPI technology.
- Continued innovation in DPI design is crucial for advancing respiratory therapeutics.
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