Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genome-wide association study of equine herpesvirus type 1-induced myeloencephalopathy identifies a significant single nucleotide polymorphism in a platelet-related gene.

Veterinary journal (London, England : 1997)·2019
Same author

Science-in-brief: Report of the Havemeyer Foundation W.R. (Twink) Allen Symposium on Equine Fertility and Assisted Reproduction.

Equine veterinary journal·2015
Same author

The equine endometrial cup reaction: a fetomaternal signal of significance.

Annual review of animal biosciences·2014
Same author

'Equine research--our only business': the Grayson-Jockey Club Research Foundation.

Equine veterinary journal·2014
Same author

Prolonged estrus suppression by ectopic transplantation of invasive equine trophoblast.

Animal reproduction science·2013
Same author

Third International Havemeyer Workshop on Equine Herpesvirus type 1.

Equine veterinary journal·2012
Same journal

Immuno-Targeting of CLRN3 and SCAMP1 as a Potential Sex Specific Marker in Bovine Spermatozoa.

Reproduction in domestic animals = Zuchthygiene·2026
Same journal

Effect of BRD0539 on Gene Editing and Mosaicism Rate in Porcine Gene Editing Embryos by CRISPR/Cas9.

Reproduction in domestic animals = Zuchthygiene·2026
Same journal

Enhancement of Ram Sperm Quality During Chilled Storage by Supplementation With Spirulina platensis Extract.

Reproduction in domestic animals = Zuchthygiene·2026
Same journal

Associations of Management Factors and Environmental Conditions With the Number of Liveborn Piglets in a Commercial Pig Farm: A Retrospective Field Study.

Reproduction in domestic animals = Zuchthygiene·2026
Same journal

Y-Sperm Enrichment Through TLR 7/8 Validated Through Molecular and Biochemical Approaches in Sahiwal Bull.

Reproduction in domestic animals = Zuchthygiene·2026
Same journal

Evaluation of Proliferative Potential and Collagen Deposition in Vitrified Canine Testicular Fragments Subjected to Different Cryoprotectant Combinations and Warming Temperatures.

Reproduction in domestic animals = Zuchthygiene·2026
See all related articles

Related Experiment Video

Updated: May 20, 2026

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
07:51

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

T-cell tolerance to the developing equine conceptus.

D F Antczak1

  • 1Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA. dfa1@cornell.edu

Reproduction in Domestic Animals = Zuchthygiene
|July 26, 2012
PubMed
Summary
This summary is machine-generated.

The mammalian fetus survives pregnancy as a semi-allograft by employing multiple immune evasion strategies. Mares provide a unique model for understanding how selective T-cell tolerance protects the conceptus.

More Related Videos

Development of an in vitro model system for studying the interaction of Equus caballus IgE with its high-affinity receptor FcεRI
07:31

Development of an in vitro model system for studying the interaction of Equus caballus IgE with its high-affinity receptor FcεRI

Published on: November 1, 2014

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Related Experiment Videos

Last Updated: May 20, 2026

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
07:51

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

Development of an in vitro model system for studying the interaction of Equus caballus IgE with its high-affinity receptor FcεRI
07:31

Development of an in vitro model system for studying the interaction of Equus caballus IgE with its high-affinity receptor FcεRI

Published on: November 1, 2014

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Area of Science:

  • Immunology
  • Reproductive Biology
  • Comparative Mammalian Studies

Background:

  • The mammalian fetus is a semi-allograft, yet it survives pregnancy without maternal rejection.
  • Graft survival typically requires genetic matching or immunosuppression, unlike the successful fetal-placental unit.
  • Understanding fetal tolerance mechanisms is crucial for reproductive success and transplantation medicine.

Purpose of the Study:

  • To review mechanisms of immune tolerance during mammalian pregnancy.
  • To highlight the role of the mare as a model for studying fetal-placental immune interactions.
  • To explore how selective T-cell tolerance protects the conceptus from maternal immune attack.

Main Methods:

  • Review of experimental data from the past 60 years on fetal-placental immune interactions.
  • Analysis of mechanisms evading maternal T lymphocyte-mediated damage.
  • Focus on evidence from equine pregnancy studies.

Main Results:

  • Fetal-placental units employ multiple strategies to avoid maternal immune detection and destruction.
  • Key mechanisms include downregulation of major histocompatibility complex (MHC) expression, maternal immune alterations, and trophoblast innate defenses.
  • Equine pregnancy studies offer insights into selective T-cell tolerance.

Conclusions:

  • Redundant protective mechanisms ensure successful pregnancy across generations.
  • Studying diverse placental forms, like those in mares, can reveal novel tolerogenic pathways.
  • These findings have potential applications in broader biology, medicine, and animal husbandry.