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Related Concept Videos

Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
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Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Angle Closure Glaucoma: Treatment

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Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
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The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
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Iris Fixation via External Pentagram Suturing
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Phlyctenular keratoconjunctivitis a potentially blinding disorder.

J R Juberias1, M Calonge, J Montero

  • 1Ocular Immunology Unit, University of Valladolid, Valladolid, Spain.

Ocular Immunology and Inflammation
|July 26, 2012
PubMed
Summary

Phlyctenular keratoconjunctivitis, an allergic eye reaction, can cause severe vision loss if untreated. This case highlights a rare bacterial cause and a novel lacrimal gland complication.

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Published on: September 20, 2018

Area of Science:

  • Ophthalmology
  • Immunology
  • Microbiology

Background:

  • Phlyctenular keratoconjunctivitis is a delayed hypersensitivity reaction to foreign proteins, often bacterial.
  • It commonly affects children and young adults sensitized to Staphylococcus aureus on the eyelids.
  • Manifestations include conjunctival and corneal inflammation.

Purpose of the Study:

  • To report a case of phlyctenular keratoconjunctivitis with unusual bacterial etiology and complications.
  • To emphasize the potential for vision impairment from this condition.
  • To document secondary lacrimal gland hypertrophy as a previously unreported complication.

Main Methods:

  • A 14-year-old female with severe keratoconjunctivitis underwent a comprehensive ocular examination.
  • Diagnostic workup included blood tests, cultures, and lid hygiene.
  • Treatment involved topical antibiotics, steroids, and oral doxycycline.

Main Results:

  • Phlyctenular keratoconjunctivitis was diagnosed, with Streptoccocus viridans identified on the lid margins.
  • Treatment resolved active inflammation and lacrimal gland enlargement.
  • Residual corneal scarring resulted in permanent visual acuity reduction.

Conclusions:

  • Untreated phlyctenular keratoconjunctivitis can lead to blinding consequences.
  • Streptoccocus viridans is an uncommon cause of this condition.
  • Secondary lacrimal gland hypertrophy is a novel complication of phlyctenular keratoconjunctivitis.