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The antibiotic resistome.

Gerard D Wright1

  • 1McMaster University, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, Hamilton, ON, L8N 3Z5, Canada. wrightge@mcmaster.ca

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The antibiotic resistome, encompassing all genes conferring resistance, offers a framework to understand antibiotic resistance evolution. Studying the resistome aids in discovering new strategies for antibiotic development.

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Area of Science:

  • Microbiology
  • Evolutionary Biology
  • Pharmacology

Background:

  • Antibiotics are crucial for treating bacterial infections, but resistance is an inevitable and rapidly emerging challenge.
  • Understanding the origins, scope, and evolution of antibiotic resistance is of paramount importance.

Purpose of the Study:

  • To review the concept of the antibiotic resistome.
  • To understand the totality of antibiotic resistance, including non-pathogenic bacteria.

Main Methods:

  • Literature review on the antibiotic resistome concept.

Main Results:

  • The antibiotic resistome includes all genes contributing to antibiotic resistance.
  • Current knowledge on the resistome concept is assembled.

Conclusions:

  • The antibiotic resistome concept provides a framework for studying resistance emergence and evolution.
  • The resistome study can inform new antibiotic discovery strategies.