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Related Experiment Video

Updated: May 20, 2026

Analysis of Cardiomyocyte Development using Immunofluorescence in Embryonic Mouse Heart
10:56

Analysis of Cardiomyocyte Development using Immunofluorescence in Embryonic Mouse Heart

Published on: March 26, 2015

Microarray analysis of normal and abnormal chick ventricular myocardial development.

E Krejčí1, Z Pesevski, A C DeAlmeida

  • 1Institute of Anatomy, First Faculty of Medicine, Charles University, Prague, Czech Republic.

Physiological Research
|July 26, 2012
PubMed
Summary
This summary is machine-generated.

This study reveals distinct gene expression patterns between chick embryonic left and right ventricles. Altered blood flow due to congenital heart defects can delay normal ventricular development.

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Area of Science:

  • Developmental biology
  • Cardiovascular research
  • Genomics

Background:

  • The left and right ventricles develop from separate cardiac precursors, exhibiting differential gene expression.
  • Understanding these developmental differences is crucial for studying congenital heart diseases.

Purpose of the Study:

  • To identify developmental gene expression differences between embryonic left and right ventricles in chicks.
  • To investigate the impact of altered hemodynamic loading on ventricular gene expression patterns.

Main Methods:

  • RNA extraction from chick embryonic ventricles at days 6, 8, and 10.
  • Microarray analysis using Affymetrix Chicken Genome array.
  • Comparison of gene expression in normal ventricles versus ventricles from hearts with induced hypoplastic left ventricles.

Main Results:

  • Identified 302 transcripts differentially expressed between left and right ventricles.
  • Detected 91 differentially expressed genes in the left ventricle and 66 in the right ventricle of ligated hearts.
  • Observed that many gene expression changes suggest a delay in normal ventricular maturation.

Conclusions:

  • Gene expression profiling reveals significant developmental disparities between embryonic ventricles.
  • Hemodynamic alterations can induce changes in gene expression, potentially delaying maturation.
  • This approach can aid in assessing surgical outcomes and timing interventions for congenital heart disease.