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Updated: May 20, 2026

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
Published on: May 9, 2025
Connection domain mutations during antiretroviral treatment failure in Mali: frequencies and impact on reverse
Almoustapha Issiaka Maiga1, Sudhir Penugonda, Drissa Katile
1Unite d'Epidemiologie Moleculaire de la Resistance du VIH aux ARV-SEREFO-FMPOS, University of Sciences Technics and Technologies of Bamako, Bamako, Mali.
Abstract:
Mutations in the connection domain (CD) of reverse transcriptase have been implicated in reverse transcriptase inhibitor (RTI) resistance, but this is controversial and little is known in non-B subtype HIV-1. We determined CD mutations prevalence in a population infected predominantly with CRF02_AG and investigated associations with phenotypic RTI resistance. Detected CD mutations were G335D (82.3%), A371V (69.8%), E399D (9.4%), N348I (5.2%), V365I (4.2), Y318F (2.1%), G333E (2.1%), and A360V (2.1%). Mutations were largely polymorphic and did not confer RTI resistance. The observed trend toward reduced likelihood of etravirine or nevirapine resistance in the presence of G335D should be investigated further.
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