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[Curative effect observation and plasma level determination in treating schizophrenia with the higher dose
1Nanjing Neuropsychiatric Institute, Jiangsu.
Zhonghua Shen Jing Jing Shen Ke Za Zhi = Chinese Journal of Neurology and Psychiatry
|October 1, 1990
Abstract:
It is reported in this article that a good curative effect was obtained when 25 schizophrenia patients were treated with 572 +/- 174(mg/day) metoclopramide. The effective rate is 80%. The metoclopramide has a good effect to controlling excitation, hallucination, delusion and thinking disorder. By determination for the metoclopramide concentration in plasma, it is observed that the active concentration and toxic concentration is signification interrelated. The half-life period of the higher dose metoclopramide in the patients is 9.11 +/- 1.72 h.