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Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
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Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

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Pediatric indications for deep brain stimulation.

Matthew F DiFrancesco1, Casey H Halpern, Howard H Hurtig

  • 1Center for Functional and Restorative Neurosurgery, Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104-4399, USA.

Child'S Nervous System : Chns : Official Journal of the International Society for Pediatric Neurosurgery
|July 26, 2012
PubMed
Summary
This summary is machine-generated.

Deep brain stimulation (DBS) shows promise for pediatric movement disorders, particularly dystonia. Further research is needed for other conditions like epilepsy and obesity in children.

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Area of Science:

  • Neurology
  • Pediatric Medicine
  • Neurosurgery

Background:

  • Deep brain stimulation (DBS) has proven effective for adult neurological disorders.
  • Its application in pediatric populations is an emerging field of study.

Purpose of the Study:

  • To review current movement disorder indications for pediatric DBS.
  • To explore potential psychiatric indications for pediatric DBS.

Main Methods:

  • Structured literature review of English-language studies from 1990-2011.
  • Searches conducted using Medline and PubMed databases for pediatric DBS research.

Main Results:

  • Twenty-four pediatric DBS reports were identified.
  • Dystonia is the most promising pediatric DBS application due to its disabling nature and low remission rate.
  • Caution is advised for conditions with high adult remission rates (e.g., OCD, Tourette's) and those with significant pediatric morbidity (epilepsy, obesity).

Conclusions:

  • Dystonia is currently the most promising pediatric DBS indication.
  • Pediatric investigation of conditions being studied in adults (epilepsy, obesity, psychiatric disorders) is warranted.