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Updated: May 20, 2026
05:25
Vascular Reconstruction with the Cuff Technique in Mouse Orthotopic Liver Transplantation
Published on: December 1, 2023
HCV in liver transplantation.
Giacomo Germani1, Emmanuel Tsochatzis, Vasilios Papastergiou
1The Royal Free Sheila Sherlock Liver Centre and University Department of Surgery, Royal Free Hospital and UCL, London, UK.
Seminars in Immunopathology
|July 26, 2012
Summary
Hepatitis C virus (HCV) recurrence after liver transplant is common, leading to cirrhosis in many. Post-transplant antiviral therapy is crucial for managing HCV recurrence and improving outcomes.
Area of Science:
- Hepatology
- Transplantation Immunology
- Virology
Background:
- Hepatocellular carcinoma (HCC) and viral hepatitis are leading causes of liver failure.
- Hepatitis C virus (HCV) related cirrhosis is a primary indication for liver transplantation in Western countries.
- HCV reinfection post-transplant is nearly universal, with significant rates of fibrosis and cirrhosis.
Purpose of the Study:
- To review factors influencing HCV recurrence post-liver transplantation.
- To discuss the impact of immunosuppression on HCV recurrence.
- To evaluate current and emerging strategies for managing post-transplant HCV infection.
Main Methods:
- Literature review of host, viral, and transplant-related factors.
- Analysis of outcomes associated with different immunosuppression strategies.
- Evaluation of pre-emptive versus delayed antiviral treatment protocols.
Main Results:
- Immunosuppression is a key factor in accelerated HCV recurrence.
- Donor age, steatosis, and immunogenetics also impact outcomes.
- Post-transplant antiviral treatment is critical for preventing rapid fibrosis.
- Retransplantation for recurrent HCV has a poor prognosis.
Conclusions:
- HCV recurrence post-liver transplant necessitates careful management.
- Optimizing immunosuppression and utilizing antiviral therapies are vital.
- New antiviral agents hold promise for improving outcomes in liver transplant recipients with HCV.
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