Utility of animal models for human embryo culture development: domestic species

Although the mouse is widely used as an animal model for the in vitro culture of human preimplantation embryos, arguments can be made for the validity of many domestic species as more relevant, applicable models of early human development. Here, we describe the advantages and disadvantages of domestic species as animal models to develop in vitro culture methods and conditions that successfully support human embryo development. In vitro embryo culture procedures are described and compared between species for the bovine, ovine, caprine, and porcine species.