Related Experiment Video
Updated: May 20, 2026

Visualizing Cellular Gibberellin Levels Using the nlsGPS1 Förster Resonance Energy Transfer (FRET) Biosensor
Published on: January 12, 2019
Bacterial GRAS domain proteins throw new light on gibberellic acid response mechanisms
Dapeng Zhang1, Lakshminarayan M Iyer, L Aravind
1National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.
Summary:
Gibberellic acids (GAs) are key plant hormones, regulating various aspects of growth and development, which have been at the center of the 'green revolution'. GRAS family proteins, the primary players in GA signaling pathways, remain poorly understood. Using sequence-profile searches, structural comparisons and phylogenetic analysis, we establish that the GRAS family first emerged in bacteria and belongs to the Rossmann fold methyltransferase superfamily. All bacterial and a subset of plant GRAS proteins are likely to function as small-molecule methylases. The remaining plant versions have lost one or more AdoMet (SAM)-binding residues while preserving their substrate-binding residues. We predict that GRAS proteins might either modify or bind small molecules such as GAs or their derivatives.
Contact:
aravind@ncbi.nlm.nih.gov
Supplementary Information:
Supplementary Material for this article is available at Bioinformatics online.
More Related Videos
Related Concept Videos
GPCRs Regulate Adenylyl Cylase Activity
Two...
Activation and Inactivation of G Proteins
Cell Signaling in Plants
Gene Regulation During Sporulation
Global Regulatory Systems
Regulation of Bacterial Virulence

