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Related Experiment Video

Updated: May 20, 2026

Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma

Patient Derived Cell Culture and Isolation of CD133⁺ Putative Cancer Stem Cells from Melanoma

Published on: March 13, 2013

Expression of stem cell markers, CD133 and CD44, in pediatric solid tumors: a study using tissue microarray.

Mitra Mehrazma¹, Zahra Madjd, Elham Kalantari

¹Department of Pathology, Tehran University of Medical Sciences, Tehran, Iran.

Fetal and Pediatric Pathology

|July 27, 2012

Summary

This summary is machine-generated.

Cancer stem cell markers CD133 and CD44 were studied in pediatric tumors. CD133 expression correlated with advanced stages in Wilms tumors and neuroblastomas, suggesting its potential as a prognostic marker.

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Isolation of CD133+ Liver Stem Cells for Clonal Expansion

Isolation of CD133+ Liver Stem Cells for Clonal Expansion

Published on: October 10, 2011

Area of Science:

Pediatric Oncology
Cancer Stem Cell Biology

Background:

The cancer stem cell (CSC) model posits that a subset of tumor cells possess self-renewal and malignant potential.
Identifying CSC markers is crucial for understanding tumor progression and developing targeted therapies.

Purpose of the Study:

To investigate the expression of cancer stem cell markers CD133 and CD44 in pediatric tumors.
To analyze the association between these markers and tumor characteristics, specifically staging.

Main Methods:

Immunohistochemistry was employed to detect CD133 and CD44 expression.
Statistical analysis was performed to correlate marker expression with tumor stage in Wilms tumors (WT) and neuroblastomas (NB).

Main Results:

A significant positive correlation was observed between CD133 expression and the National Wilms Tumor Stage (NWTS) in WT (p = 0.047).
CD133 expression positively correlated with the International Neuroblastoma Staging System (INSS) in NB (p = 0.012), with higher stages showing increased positivity.
CD44 expression analysis is also mentioned but specific correlations with staging were not detailed in the provided text.

Conclusions:

CD133 is a putative stem cell marker associated with advanced stages in both Wilms tumors and neuroblastomas.
CD133 holds potential as a clinical prognostic marker for children diagnosed with NB or WT.