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Interaction of extracellular vesicles of Bacteroides gingivalis W50 with human polymorphonuclear leucocytes
H M Kay1, A J Birss, J W Smalley
1Department of Clinical Dental Sciences, University of Liverpool, U.K.
FEMS Microbiology Letters
|October 1, 1990
Abstract:
The effects of B. gingivalis W50 extracellular vesicles (ECV) on neutrophil chemotaxis and viability were assessed and compared with those of whole cells and the extracellular non-dialysable soluble protein (EP) fraction. None of the fractions tested, including soluble fractions derived from cells and ECV by sonication, induced neutrophil chemotaxis. Only ECV and cells inhibited f-MLP-stimulated chemotaxis. ECV and cells were cytotoxic towards neutrophils. The cytotoxic response was time dependent. The soluble EP fraction did not influence cell viability.