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Adhesive binding of rokitamycin to Staphylococcus aureus ribosomes
K Endou1, M Matsuoka, Y Nakajima
1Division of Microbiology, Hokkaido Institute of Pharmaceutical Sciences, Japan.
FEMS Microbiology Letters
|October 1, 1990
Abstract:
Rokitamycin (RKM), a 3"-O-propionyl derivative of leucomycin A5, is bactericidal against staphylococci near the minimum inhibitory concentrations. RKM bound to ribosomes before-hand is only slightly displaced by erythromycin or josamycin, or even by RKM itself. The adhesive binding of the RKM-ribosome complex might prove to be the lethal event for susceptible staphylococci.