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Related Experiment Video

Updated: May 20, 2026

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

Published on: November 30, 2016

Is tissue cross-talk important in cancer cachexia?

Neil Johns¹, C Greig, Kenneth C H Fearon

¹Department of Clinical Surgery and Geriatrics, School of Clinical Sciences and Community Health, University of Edinburgh, Edinburgh, EH16 4SB, UK.

Critical Reviews in Oncogenesis

|July 27, 2012

Summary

Molecular communication between fat and muscle tissue influences body composition and chronic diseases. Targeting this cross-talk, particularly in cancer cachexia, offers potential therapeutic benefits.

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A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

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Last Updated: May 20, 2026

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

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Published on: November 30, 2016

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

Published on: September 20, 2016

Area of Science:

Integrative physiology
Exercise physiology
Endocrinology

Background:

Molecular cross-talk between adipose and muscle tissue involves adipokines and myokines.
This endocrine signaling regulates body composition in health and disease.
Chronic inflammation, lipolysis, and free fatty acids in adipose-muscle cross-talk contribute to insulin resistance and lipotoxicity, particularly in obesity and diabetes.

Purpose of the Study:

To review the molecular cross-talk between adipose and muscle tissue.
To highlight the role of adipokines and myokines in regulating body composition.
To explore therapeutic potential in manipulating adipose-muscle physiology for conditions like cancer cachexia.

Main Methods:

Literature review of exercise physiology and integrative physiology studies.
Analysis of molecular signaling pathways between adipose and muscle tissue.
Examination of the role of inflammation, lipolysis, and insulin resistance.

Main Results:

Adipokines and myokines are key mediators of adipose-muscle cross-talk.
Dysregulated cross-talk contributes to chronic diseases like obesity, diabetes, and cancer cachexia.
Cancer cachexia involves systemic inflammation, lipolysis, insulin resistance, and reduced activity.

Conclusions:

The molecular dialogue between adipose and muscle tissue is crucial for metabolic health.
Understanding this cross-talk offers avenues for novel therapeutic strategies.
Targeting adipose-muscle interactions may improve treatment outcomes and survival in cancer cachexia.