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In Vivo Imaging Systems (IVIS) Detection of a Neuro-Invasive Encephalitic Virus
Published on: December 2, 2012
Acute necrotizing encephalopathy associated with enterovirus infection
Brahim Tabarki1, Farah Thabet, Shatha Al Shafi
1Division of Pediatric Neurology, Department of Pediatrics, Riyadh Military Hospital, Riyadh, Saudi Arabia. btabarki@hotmail.com
Brain & Development
|July 27, 2012
Summary
Acute necrotizing encephalopathy, a rare brain condition, can be triggered by viral infections. This case highlights a successful treatment with steroids in a Saudi child, despite delayed intervention.
Area of Science:
- Neurology
- Pediatrics
- Infectious Diseases
Background:
- Acute necrotizing encephalopathy (ANE) is a rare neurological disorder.
- It is characterized by acute encephalopathy often triggered by febrile illnesses, primarily viral infections.
- ANE is frequently associated with uncontrolled cytokine release and predominantly observed in East Asia.
Observation:
- This report details a rare case of ANE in a 4-year-old Saudi girl.
- The patient's condition was linked to an enterovirus infection.
- Elevated levels of interleukin-6 and tumor necrosis factor-alpha were noted in serum and cerebrospinal fluid.
Findings:
- The patient experienced severe magnetic resonance imaging findings.
- Treatment with intravenous pulse methylprednisolone was initiated despite a delay.
- The patient demonstrated a good clinical outcome following steroid therapy.
Implications:
- This case represents the first reported instance of ANE in Saudi Arabia with a favorable outcome.
- It underscores the potential efficacy of steroid treatment in ANE, even with delayed administration and significant imaging abnormalities.
- The findings contribute to understanding ANE's presentation and management in diverse geographical regions.
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