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Related Experiment Video

Updated: May 20, 2026

Assessment of Sexual Behavior of Male Mice

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Published on: March 5, 2020

Abnormal behavior in mice mutant for the Disc1 binding partner, Dixdc1.

S Kivimäe¹, P-M Martin, D Kapfhamer

¹Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94158, USA.

Translational Psychiatry

|July 27, 2012

Summary

This summary is machine-generated.

Mice lacking the DIX domain containing 1 (Dixdc1) gene showed abnormal behaviors, including reduced activity and altered startle responses. These findings suggest Dixdc1

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Generation, Purification, and Characterization of Cell-invasive DISC1 Protein Species

Generation, Purification, and Characterization of Cell-invasive DISC1 Protein Species

Published on: August 30, 2012

Area of Science:

Neuroscience
Genetics
Molecular Biology

Background:

Disrupted-in-Schizophrenia-1 (DISC1) is a key genetic factor in schizophrenia and depression.
DISC1 interacts with DIX domain containing 1 (Dixdc1), influencing neural progenitor proliferation and migration.
Both DISC1 and Dixdc1 are implicated in Wnt signaling pathways crucial for neural development.

Purpose of the Study:

To investigate the behavioral consequences of Dixdc1 gene mutations in mice.
To explore the potential role of Dixdc1 in the pathophysiology of major mental illnesses.
To establish Dixdc1 mutant mice as a model for studying DISC1-related disorders.

Main Methods:

Generation of Dixdc1 knockout (Dixdc1(-/-)) mice.
Behavioral analysis including prepulse inhibition, locomotor activity, elevated plus maze, and startle reactivity.
Comparison of Dixdc1(-/-) mice with wild-type controls.

Main Results:

Dixdc1(-/-) mice exhibited normal prepulse inhibition.
Significant decreases in spontaneous locomotor activity were observed.
Abnormal behaviors in the elevated plus maze and deficits in startle reactivity were noted.

Conclusions:

Dixdc1 plays a role in regulating specific behaviors relevant to mental health.
Dixdc1(-/-) mice represent a valuable model for investigating the molecular mechanisms underlying DISC1-associated mental illnesses.
Further research using this model can elucidate the pathophysiology of schizophrenia and depression.