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Barrett Esophagus-II: Clinical Manifestations and Management

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Related Experiment Video

Updated: May 20, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

Published on: May 10, 2024

[Eosinophilic esophagitis: update 2012].

¹Department of Internal Medicine, Eulji University School of Medicine, Seoul, Korea. jyj1138@eulji.ac.kr

The Korean Journal of Gastroenterology = Taehan Sohwagi Hakhoe Chi

|July 27, 2012

Summary

This summary is machine-generated.

Eosinophilic esophagitis (EoE) is a chronic immune disorder causing esophageal inflammation and symptoms. Diagnosis involves genetic factors and excludes proton pump inhibitor-responsive eosinophilia.

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Area of Science:

Gastroenterology
Immunology
Pathology

Context:

Eosinophilic esophagitis (EoE) is a recently recognized clinicopathologic disorder.
It presents with esophageal eosinophilic infiltration and related symptoms in adults.
An updated consensus in July 2011 refined the understanding of EoE.

Purpose:

To define Eosinophilic Esophagitis (EoE) as a chronic, immune/antigen-mediated esophageal disease.
To highlight key diagnostic features including clinical symptoms and histological findings.
To incorporate genetic associations and recent diagnostic considerations.

Summary:

EoE is characterized by esophageal dysfunction symptoms and eosinophil-predominant inflammation.
Genetic factors, such as thymic stromal lymphopoietin and filaggrin genes, are implicated in EoE susceptibility.
Concurrent allergic diseases, particularly food or aeroallergen sensitization, are common in EoE patients.
Topical steroids and dietary modifications are primary treatments.
Proton pump inhibitor-responsive esophageal eosinophilia must be excluded for an accurate EoE diagnosis.

Impact:

Provides a refined conceptual definition of EoE.
Identifies key genetic susceptibility factors.
Clarifies diagnostic criteria, including exclusions.
Informs clinical management strategies for EoE.