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Two new compounds isolated from Liriope muscari.

Wen-Jie Li1, Zhi-Hao Zhang, Xian-Long Cheng

  • 1National Institutes for Food and Drug Control, Beijing 100050, China. lwj115@163.com

Molecules (Basel, Switzerland)
|July 27, 2012
PubMed
Summary

Two novel compounds, norcurlignan and limlactone, were isolated from Liriope muscari. These compounds, along with a known one, showed antioxidant activity in DPPH and ABTS assays.

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Area of Science:

  • Natural Product Chemistry
  • Pharmacognosy
  • Medicinal Chemistry

Background:

  • Liriope muscari is a plant with traditional medicinal uses.
  • Phytochemical investigation of Liriope species can yield novel bioactive compounds.

Purpose of the Study:

  • To isolate and characterize new chemical constituents from Liriope muscari.
  • To evaluate the in vitro antioxidant potential of the isolated compounds.

Main Methods:

  • Isolation of compounds using chromatographic techniques.
  • Structure elucidation via 1D NMR, 2D NMR, Circular Dichroism (CD), and Mass Spectrometry (MS).
  • In vitro antioxidant activity assessment using DPPH and ABTS radical scavenging assays.

Main Results:

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  • Two new compounds, norcurlignan (1) and limlactone (2), were identified.
  • The known compound (-)-pinoresinol (3) was also isolated.
  • Compounds 1-3 demonstrated varying degrees of in vitro antioxidant activity.

Conclusions:

  • Liriope muscari is a source of novel lignans and lactones.
  • The isolated compounds possess antioxidant properties, warranting further investigation for therapeutic potential.