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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
An ent-kaurane-type diterpene in Croton antisyphiliticus mart
Sarazete Pereira1, Silvia Taleb-Contini, Juliana Coppede
1Department of Biotechnology, University of Ribeirão Preto (UNAERP), Av. Costábile Romano, 2201, CEP 14096-900, Ribeirão Preto, SP, Brazil.
Abstract:
Croton antisyphiliticus is a medicinal plant widely used in the treatment of microbial infections, especially those affecting the genital tract. Crude extract, fractions and pure compound isolated from roots of this species were investigated to validate their antimicrobial activity against Escherichia coli and Staphylococcus aureus. The compound ent-kaur-16-en-18-oic acid was isolated as a major component (0.7% of crude extract), and its MIC value determined against S. aureus (ATCC 6538) was 250 μg/mL. This is the first phytochemical work on the species monitored with antimicrobial assay.
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