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Coronary sclerosis risk factors in males with special reference to lipoproteins and apoproteins: establishing an
M Kawanishi1, A Nakamoto, G Konemori
1Department of Biometrics, Hiroshima University, Japan.
Insights
This study identifies key lipid and apoprotein markers for predicting coronary sclerosis in men over 44. Higher Apo-B/Apo-AI ratios significantly increase the risk of coronary artery disease.
Area of Science:
- Cardiology
- Biochemistry
- Preventive Medicine
Background:
- Coronary sclerosis risk assessment requires effective predictive indices.
- Lipid and apoprotein profiles are crucial in cardiovascular disease pathogenesis.
Purpose of the Study:
- To determine the most effective serum index for predicting coronary sclerosis.
- To evaluate the association of lipids, lipoproteins, and apoproteins with coronary artery disease.
Main Methods:
- Serum lipid, lipoprotein, and apoprotein concentrations were measured.
- Analysis included 45 males with diagnosed effort angina and 153 male controls.
- Statistical analysis adjusted for confounding factors like alcohol and smoking.
Main Results:
- High alcohol and cigarette consumption were associated with modified coronary sclerosis risk (OR 0.47 and 2.33).
- Decreased High-Density Lipoprotein Cholesterol (HDLC) and Apolipoprotein AI (Apo-AI) levels doubled the risk.
- Low-Density Lipoprotein Cholesterol/HDLC (LDLC/HDLC) and Apolipoprotein B/Apo-AI (Apo-B/Apo-AI) ratios effectively predicted coronary sclerosis.
Conclusions:
- The Apo-B/Apo-AI ratio is a highly effective predictor of coronary sclerosis.
- Elevated Apo-B/Apo-AI ratios significantly increase the probability of developing coronary artery disease.
Abstract:
In order to ascertain the most effective index for predicting coronary sclerosis, the concentration of lipids, lipoproteins, and apoproteins in serum were determined in 45 males aged over 44 with angiographically diagnosed effort angina and in 153 male controls aged over 44 without ischemic heart disease (IHD) on physical examination. The results of our study are summarized as follows. 1) Alcohol intake of 25 g/day or more and smoking of 20 cigarettes/day or more showed significant odds ratios of 0.47 and 2.33, respectively. 2) By decrease of 10 mg/dl in HDLC level or of 10 mg/dl in Apo-AI level, the possibility of coronary sclerosis increases twofold after adjusting the effects of confounders. 3) LDLC/HDLC and Apo-B/Apo-AI are effective indices for predicting coronary sclerosis and, in particular, the probability of coronary sclerosis increases 3.8 times by increase of 0.5 in Apo-B/Apo-AI.