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Amino Acid Biosynthetic Pathways01:29

Amino Acid Biosynthetic Pathways

Amino acid biosynthesis is essential for cell growth, protein synthesis, and metabolic regulation. Cells generate essential and non-essential amino acids from metabolic intermediates to sustain vital biological functions. These intermediates originate from key metabolic pathways: glycolysis, the tricarboxylic acid (TCA) cycle, and the pentose phosphate pathway. Important precursors include α-ketoglutarate, pyruvate, oxaloacetate, phosphoenolpyruvate, and erythrose-4-phosphate, which provide...
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The Proteasome Structure

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Proteins: From Genes to Degradation02:11

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Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
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Published on: June 20, 2014

Lasso peptides: structure, function, biosynthesis, and engineering.

Mikhail O Maksimov1, Si Jia Pan, A James Link

  • 1Department of Chemical and Biological Engineering, Princeton University, NJ 08544, USA.

Natural Product Reports
|July 27, 2012
PubMed
Summary
This summary is machine-generated.

This review covers lasso peptides, natural products with diverse bioactivities. It details their structure, biosynthesis, discovery, and engineering, highlighting current knowledge and future research directions for these unique molecules.

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Area of Science:

  • Natural Product Chemistry
  • Biochemistry
  • Bioinformatics

Background:

  • Lasso peptides are ribosomally synthesized and post-translationally modified natural products.
  • These molecules exhibit a wide range of biological activities.
  • Understanding their structure and function is crucial for various applications.

Purpose of the Study:

  • To provide a comprehensive overview of known lasso peptides as of mid-2012.
  • To review the biosynthesis pathways of lasso peptides.
  • To discuss methods for discovering and engineering novel lasso peptides.

Main Methods:

  • Literature review of existing studies on lasso peptides.
  • Analysis of structural and functional data.
  • Examination of biosynthetic pathways and bioinformatics discovery strategies.
  • Highlighting engineering studies and future research avenues.

Main Results:

  • Detailed description of the structure and function of known lasso peptides.
  • Summary of current knowledge on lasso peptide biosynthesis.
  • Overview of isolation, characterization, and bioinformatics discovery techniques.
  • Examples of engineered lasso peptides with modified functions.

Conclusions:

  • Lasso peptides represent a fascinating class of natural products with significant potential.
  • Continued research in biosynthesis, discovery, and engineering will unlock new applications.
  • Further investigation is needed to address unanswered questions in the field.