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Related Concept Videos

Selectins01:25

Selectins

Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...

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Mannose-binding lectin levels and variation during invasive candidiasis.

Sébastien Damiens1, Julien Poissy, Nadine François

  • 1Université Lille Nord de France, Lille Cedex, France.

Journal of Clinical Immunology
|July 27, 2012
PubMed
Summary

Mannose-binding lectin (MBL) levels are higher in invasive candidiasis (IC) patients, but decrease before positive blood cultures. This suggests MBL

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Area of Science:

  • Immunology
  • Infectious Diseases
  • Clinical Microbiology

Background:

  • Invasive candidiasis (IC) presents significant hospital morbidity and mortality.
  • Mannose-binding lectin (MBL) is crucial for innate immunity, interacting with Candida albicans.
  • Previous studies linked MBL deficiency to specific candidiasis forms.

Purpose of the Study:

  • To investigate circulating MBL levels in patients with IC.
  • To analyze MBL level dynamics during the course of IC.
  • To explore the relationship between MBL, mannan, and anti-mannan antibodies in IC.

Main Methods:

  • Serum MBL levels were quantified using enzyme-linked immunosorbent assay (ELISA).
  • Study included 68 IC patients, 82 hospitalized patients (HP), and 70 healthy subjects (HS).
  • MBL concentrations were monitored throughout the IC disease progression.

Main Results:

  • MBL levels were significantly elevated in IC patients compared to HP and HS.
  • A marked decrease in MBL concentration was observed preceding positive blood cultures.
  • This MBL decline correlated with high levels of circulating mannan (Mn).
  • Anti-mannan antibodies (AMn) increased post-mannanemia/blood culture.

Conclusions:

  • MBL may play a role in the early stages of invasive candidiasis.
  • The observed changes in MBL, mannan, and antibodies warrant further investigation.
  • Understanding these mechanisms is vital for assessing IC prognosis and immune response.