Related Experiment Video
Updated: May 20, 2026
08:43
Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase (G6PI)-Induced RA Mice
Published on: January 31, 2020
Comparison between steroid pulse therapy alone and in combination with tonsillectomy for IgA nephropathy
Ayami Ochi1, Takahito Moriyama, Takashi Takei
1Department of Medicine, Kidney Center, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.
International Urology and Nephrology
|July 27, 2012
Summary
Tonsillectomy combined with steroid pulse therapy significantly improved remission rates for IgA nephropathy (IgAN) patients compared to steroid pulse therapy alone. This combination therapy offers a promising treatment approach for IgAN.
Area of Science:
- Nephrology
- Immunology
- Otolaryngology
Background:
- IgA nephropathy (IgAN) is a common cause of glomerulonephritis.
- Tonsillectomy is increasingly recognized as a potential treatment modality for IgAN.
- Intermittent steroid pulse therapy is a standard treatment for IgAN.
Purpose of the Study:
- To compare the efficacy of intermittent steroid pulse therapy with and without tonsillectomy in IgA nephropathy patients.
- To evaluate clinical and histological findings, and remission rates after 1 year of treatment.
Main Methods:
- Retrospective cohort analysis of 41 IgAN patients.
- Comparison between tonsillectomy plus steroid pulse therapy (TSP group, n=26) and steroid pulse therapy alone (SP group, n=15).
- Assessment of remission rates based on urinary protein excretion and red blood cell count.
Main Results:
- No significant difference in baseline characteristics between groups.
- Higher remission rates for urinary red blood cells (88.4% vs 33.3%) and overall remission (69.2% vs 13.3%) in the TSP group.
- Combination therapy showed a significantly higher remission rate (OR, 12.5; P=0.0002).
Conclusions:
- Tonsillectomy combined with steroid pulse therapy significantly improved remission rates in IgAN patients after one year.
- This combination therapy is more effective than steroid pulse monotherapy.
- Further studies are needed to assess long-term renal survival.
Related Concept Videos
01:26Nephrotic Syndrome II : Assessment and Medical Management
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
01:26Tonsillitis II: Management
This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
01:24Nephrotic Syndrome I : Introduction
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
01:26Kidney Transplant II: Surgical Procedure
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
01:23Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
01:28Acute Pyelonephritis II: Diagnostic Studies and Management
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...