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MTG16 contributes to colonic epithelial integrity in experimental colitis

Christopher S Williams1, Amber M Bradley, Rupesh Chaturvedi

  • 1Department of Medicine, Division of Gastroenterology, Vanderbilt University, Nashville, Tennessee, USA.

Gut
|July 27, 2012
PubMed
Summary

Myeloid translocation gene 16 (MTG16) is crucial for maintaining intestinal integrity. MTG16 deficiency in mice leads to severe colitis, increased inflammation, and impaired regeneration after injury, highlighting its role in colon health.

Keywords:
ColitisCrohn's colitisHelicobacter pyloriHelicobacter pylori infectionHelicobacter pylori—pathogenesisIBDIBD basic researchIBD—geneticsMtg16angiogenesisbacterial pathogenesiscancercarcinogenesiscolon carcinogenesiscolorectal cancercolorectal diseasescytokinesdextran sulphate sodiumexperimental colitisgastrointestinal pathologygene expressionimmunityinflammatory bowel diseaseinflammatory mechanismsintestinal T cellsmatrix metalloproteinaseulcerativewound-healing

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