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Updated: May 20, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Switching the stereoselectivity: (fullero)pyrrolidines "a la carte"
Enrique E Maroto1, Salvatore Filippone, Angel Martín-Domenech
1Departamento de Química Orgánica I, Facultad de Química, Universidad Complutense , E-28040 Madrid, Spain.
Abstract:
Stereodivergent syntheses of cis/trans pyrrolidino[3,4:1,2]fullerenes and endo/exo pyrrolidines are reported with high enantioselectivity levels. Fullerenes are revealed as a useful benchmark to develop suitable catalysts to control the stereochemical outcome and to shed light on the mechanism involved in the related 1,3-dipolar cycloaddition.
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