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Metal-Ligand Bonds

Metal-Ligand Bonds

The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...

Complexation Equilibria: The Chelate Effect

Complexation Equilibria: The Chelate Effect

In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...

Complexation Equilibria: Factors Influencing Stability of Complexes

Complexation Equilibria: Factors Influencing Stability of Complexes

In complexation reactions, metal cations are the electron pair acceptors, and the ligands are the electron pair donors. The stability of the metal complexes depends primarily on the complexing ability of the central metal ion and the nature of the ligands. Generally, the complexing ability of the metal ion depends on the size and charge of the ion. As the metal ion size increases, the stability of the metal complexes decreases, provided that the valency of the metal ion and the ligands remain...

Complexometric Titration: Ligands

Complexometric Titration: Ligands

Different monodentate and polydentate ligands are used as complexing agents in complexometric titration reactions. The formation of complexes by mono- and bidentate ligands involves two or more intermediate steps, limiting their use as complexing agents. In comparison, polydentate ligands can form complexes with metal ions in a single-step process, facilitating sharper end points. This means polydentate ligands, such as amino carboxylic acid derivatives, are most commonly employed in...

Properties of Organometallic Compounds

Properties of Organometallic Compounds

Organometallic compounds are compounds that contain a carbon–metal bond. Carbon belongs to an organyl group like alkyl, aryl, allyl, or benzyl groups. The metal can be from Group I or Group II of the periodic table, a transition metal, or a semimetal.

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Updated: May 20, 2026

Synthesis of a Water-soluble Metal–Organic Complex Array

Synthesis of a Water-soluble Metal–Organic Complex Array

Published on: October 8, 2016

Bioactive polymeric metallosomes self-assembled through block copolymer-metal complexation.

Kensuke Osada¹, Horacio Cabral, Yuki Mochida

¹Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

Journal of the American Chemical Society

|July 28, 2012

Summary

Researchers developed novel polymeric metallosomes using an anticancer drug and a block copolymer. These self-assembled structures effectively deliver drugs to tumors and enable fluorescent imaging, showing promise as multifunctional drug carriers.

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Synthesis and Characterization of Self-Assembled Metal-Organic Framework Monolayers Using Polymer-Coated Particles

Synthesis and Characterization of Self-Assembled Metal-Organic Framework Monolayers Using Polymer-Coated Particles

Published on: June 14, 2024

Area of Science:

Biomaterials Science
Nanotechnology
Polymer Chemistry

Background:

Polymeric metallosomes offer potential for targeted drug delivery.
Developing self-assembled nanostructures with controlled drug release is crucial for cancer therapy.

Purpose of the Study:

To investigate the spontaneous formation of polymeric metallosomes.
To evaluate their potential for drug delivery and tumor imaging.

Main Methods:

Reaction of (1,2-diaminocyclohexane)platinum(II) (DACHPt) with a Y-shaped block copolymer (PEGasus-PLGA-Chole).
Characterization using circular dichroism spectroscopy.
In vivo studies in mice for drug delivery and tumor imaging.

Main Results:

Uniform (~100 nm) polymeric metallosomes formed spontaneously in aqueous medium.
PLGA segment adopted an α-helix structure, driving self-assembly into vesicular structures.
Metallosomes successfully encapsulated macromolecules, delivered them to tumors, and enabled fluorescent imaging with demonstrated antitumor activity.

Conclusions:

Self-assembled polymeric metallosomes show potential as multifunctional drug carriers.
The system facilitates targeted delivery of anticancer agents and imaging agents to tumors.
The secondary structure formation of the PLGA segment plays a key role in the self-assembly process.