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Related Concept Videos

Introduction to Fibroblasts01:09

Introduction to Fibroblasts

Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...
The Extracellular Matrix01:42

The Extracellular Matrix

Overview
The Extracellular Matrix01:29

The Extracellular Matrix

Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Phases of Wound Repair01:28

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...

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Related Experiment Video

Updated: May 20, 2026

3D Bioprinting Phototunable Hydrogels to Study Fibroblast Activation
07:17

3D Bioprinting Phototunable Hydrogels to Study Fibroblast Activation

Published on: June 30, 2023

Fibroblast activation protein in remodeling tissues.

M Jacob1, L Chang, E Puré

  • 1Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.

Current Molecular Medicine
|July 28, 2012
PubMed
Summary

Fibroblast activation protein (FAP) is a selective marker for reactive stromal cells involved in tissue remodeling. Targeting FAP offers potential therapeutic benefits for various diseases.

Area of Science:

  • Cell Biology
  • Biochemistry
  • Pathology

Background:

  • Tissue remodeling is crucial for development and healing but also implicated in diseases like fibrosis and cancer.
  • Reactive stromal cells are key players in these processes, yet their heterogeneity and diverse origins complicate study.
  • A specific molecular marker for these cells has been lacking.

Purpose of the Study:

  • To review evidence supporting Fibroblast Activation Protein (FAP) as a robust marker for reactive mesenchymal stromal cells.
  • To explore FAP's role in understanding reactive stromal cell subpopulations and their functions.
  • To discuss the therapeutic potential and risks of targeting FAP and FAP-expressing cells.

Main Methods:

  • Literature review of studies on tissue remodeling and reactive stromal cells.

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Development of an In Vitro Assay to Evaluate Contractile Function of Mesenchymal Cells that Underwent Epithelial-Mesenchymal Transition

Published on: June 10, 2016

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Last Updated: May 20, 2026

3D Bioprinting Phototunable Hydrogels to Study Fibroblast Activation
07:17

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06:02

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Published on: June 10, 2016

  • Analysis of data utilizing FAP as a selective marker.
  • Examination of genetic and pharmacologic research on FAP's function and therapeutic targeting.

    • Main Results:

    • FAP is a reliable and selective marker for reactive mesenchymal stromal cells in pathophysiologic tissue remodeling.
    • FAP aids in defining relationships between subpopulations of reactive stromal cells.
    • FAP and FAP-expressing cells play significant roles in disease pathogenesis.

    Conclusions:

    • FAP is a valuable tool for studying reactive stromal cells in tissue remodeling.
    • Targeting FAP presents therapeutic opportunities and risks that warrant further investigation.
    • Understanding FAP's role is critical for developing novel treatments for fibrotic and cancerous conditions.