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In Vivo Immunogenicity Screening of Tumor-Derived Extracellular Vesicles by Flow Cytometry of Splenic T Cells
Published on: September 23, 2021
Tumor-derived microvesicles and the cancer microenvironment.
G Camussi1, M C Deregibus, C Tetta
1Department of Internal Medicine, Molecular Biotechnology Center and Centre for Research in Experimental Medicine (CeRMS), Torino, Italy. giovanni.camussi@unito.it
Current Molecular Medicine
|July 28, 2012
Summary
Tumor cells release microvesicles (MVs) that mediate communication by transferring signals, proteins, and genetic material. These MVs play a crucial role in altering recipient cell function and the tumor microenvironment.
Area of Science:
- Oncology
- Cell Biology
- Molecular Biology
Background:
- Tumor cells release microvesicles (MVs) into the extracellular environment.
- These MVs can remain localized or travel to distant sites via biological fluids.
- Microvesicles are increasingly recognized as key mediators of intercellular communication.
Purpose of the Study:
- To review the biological actions of tumor-derived microvesicles.
- To discuss the potential role of MVs in tumor biology and cancer progression.
Main Methods:
- Literature review of studies on tumor-derived microvesicles.
- Analysis of mechanisms of MV-mediated intercellular communication.
- Examination of MV cargo, including proteins, lipids, and nucleic acids.
Main Results:
- MVs transfer bioactive molecules like lipids, proteins, mRNA, and microRNA from tumor cells to recipient cells.
- Tumor-derived MVs can induce epigenetic changes and alter the phenotype and function of stromal cells.
- MVs facilitate both local and long-range cell-to-cell signaling within the tumor microenvironment.
Conclusions:
- Tumor-derived microvesicles are significant effectors of cell-to-cell communication.
- MVs contribute to the modulation of the tumor microenvironment and influence tumor progression.
- Understanding MV biology offers potential therapeutic and diagnostic opportunities.
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