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Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
Published on: May 1, 2015
Giant benign lymphangioendothelioma.
Juan M Revelles1, Jose L Díaz, Jorge Angulo
1Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.
Journal of Cutaneous Pathology
|July 28, 2012
Summary
Benign lymphangioendothelioma is a rare vascular neoplasm. This case report details a giant example, highlighting Wilms tumor 1 gene positivity to confirm its neoplastic nature.
Area of Science:
- Dermatology
- Pathology
- Oncology
Background:
- Benign lymphangioendothelioma is a rare, locally infiltrative vascular neoplasm.
- It typically presents as a slow-growing, asymptomatic, reddish-violaceous plaque.
- Histopathology reveals irregular, thin-walled vascular spaces dissecting dermal collagen.
Observation:
- A case of a giant benign lymphangioendothelioma in a 75-year-old male is presented.
- This represents the largest documented case in medical literature.
- The lesion exhibited characteristic histopathological features.
Findings:
- Immunohistochemical analysis showed positivity for Wilms tumor 1 gene (WT1).
- WT1 expression is a valuable tool in distinguishing vascular malformations from proliferative endothelial lesions.
- The WT1 positivity in this case supported the neoplastic nature of the benign lymphangioendothelioma.
Implications:
- This case expands the understanding of benign lymphangioendothelioma size variations.
- WT1 immunohistochemistry is confirmed as a useful marker for diagnosing endothelial neoplasms.
- Accurate diagnosis is crucial for appropriate management of vascular lesions.