Related Experiment Video
Updated: May 20, 2026

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
Published on: October 27, 2020
How does TGF-β mediate tubulointerstitial fibrosis?
1Department of Research, Veterans Affairs Hospital, Tennessee Valley Healthcare System, Nashville, TN, USA. leslie.gewin@vanderbilt.edu
Abstract:
Tubulointerstitial fibrosis mediates the development of end-stage renal disease from renal injuries of all etiologies and is considered an important predictor of renal survival. Transforming growth factor-β (TGF-β) is one of the most important growth factors that promotes tubulointerstitial fibrosis, but the mechanisms whereby this occurs are not well defined. This is because TGF-β has pleiotropic effects that depend on the target cell type. This review discusses how TGF-β signaling in each of the relevant cell types (eg, tubular epithelium, fibroblasts) may contribute to tubulointerstitial fibrosis progression and suggests ways in which future research can improve our understanding of TGF-β-mediated tubulointerstitial fibrosis.
More Related Videos
Related Concept Videos
TGF - β Signaling Pathway
Chronic Inflammation: Introduction
Intracellular Signaling Affects Focal Adhesions
Some...
Inflammatory Bowel Disease III: Crohn's Disease
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

