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Updated: May 20, 2026
Harvesting Murine Alveolar Macrophages and Evaluating Cellular Activation Induced by Polyanhydride Nanoparticles
Published on: June 8, 2012
Pilot study on effects of nanoparticle exposure on Crassostrea virginica hemocyte phagocytosis
Talia E Abbott Chalew1, Justin F Galloway, Thaddeus K Graczyk
1Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, E6628, Baltimore, MD 21205, United States. tchalew@jhsph.edu
Abstract:
Little is known about engineered nanoparticles (NPs) exposures on oysters. As sessile filter feeders, oysters are likely to be exposed to NPs suspended in the water column with unknown effects of NP exposure on oyster functioning. Our study indicates that waterborne NPs alter oyster hemocyte phagocytosis dynamics, an indication of sub-lethal effects of NP exposures. Silver NPs, titanium dioxide (TiO(2)) NPs, and silver nitrate exposures reduced phagocytosis compared to the control. Increasing TiO(2) NPs and silver nitrate concentrations reduced phagocytosis. Silver NPs, up to 120ppb, increased phagocytosis, but higher concentrations reduced phagocytosis.
