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Related Experiment Video

Updated: May 20, 2026

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets

Published on: May 11, 2015

Pulsed or continuous flow in long-term assist devices: a debated topic.

Fabrizio Sansone¹, Edoardo Zingarelli, Roberto Flocco

¹Division of Cardiac Surgery, Mauriziano Umberto I Hospital, L.goTurati 62, 10135 Turin, Italy. fabrisans@katamail.com

Transplantation Reviews (Orlando, Fla.)

|July 28, 2012

Summary

End-stage cardiomyopathy requires alternative treatments as donor hearts are scarce. Continuous flow left ventricular assist devices offer improved survival and reliability over pulsatile flow options, despite ongoing debates.

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Characterization of the Isolated, Ventilated, and Instrumented Mouse Lung Perfused with Pulsatile Flow

Characterization of the Isolated, Ventilated, and Instrumented Mouse Lung Perfused with Pulsatile Flow

Published on: April 29, 2011

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Last Updated: May 20, 2026

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets

Published on: May 11, 2015

Characterization of the Isolated, Ventilated, and Instrumented Mouse Lung Perfused with Pulsatile Flow

Characterization of the Isolated, Ventilated, and Instrumented Mouse Lung Perfused with Pulsatile Flow

Published on: April 29, 2011

Area of Science:

Cardiology
Biomedical Engineering
Medical Devices

Background:

End-stage cardiomyopathy is a growing global health concern.
Limited donor availability for cardiac transplantation necessitates alternative strategies.
Left ventricular assist devices (LVADs) are increasingly used for long-term patient support, improving survival rates.

Purpose of the Study:

To review the current literature comparing continuous flow and pulsatile flow LVADs for long-term support.
To analyze the evidence regarding the risks and benefits of different flow types in LVADs.
To discuss the implications of flow dynamics on patient outcomes, including gastrointestinal complications.

Main Methods:

Literature review of studies on continuous and pulsatile flow LVADs.
Analysis of evidence on pump reliability, surgical morbidity, and patient survival.
Examination of complications associated with different flow types, focusing on gastrointestinal issues.

Main Results:

Continuous flow LVADs demonstrate lower surgical morbidity and better long-term reliability compared to pulsatile devices.
There is a significant clinical trend towards adopting continuous flow devices.
Evidence on the long-term benefits and risks of pulsatile versus continuous flow is still debated, with gastrointestinal complications being a key consideration.

Conclusions:

Continuous flow LVADs represent a promising advancement in managing end-stage cardiomyopathy due to their practical advantages.
Further research is needed to fully elucidate the long-term implications of continuous flow support, particularly concerning potential complications.
The choice between pulsatile and continuous flow LVADs requires careful consideration of individual patient factors and the evolving evidence base.