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Related Experiment Video

Updated: May 20, 2026

Primary Culture of Dental Pulp Stem Cells

Primary Culture of Dental Pulp Stem Cells

Published on: May 5, 2023

Regenerative therapy: a periodontal-endodontic perspective.

Bassam Michael Kinaia¹, Sami M A Chogle, Atheel M Kinaia

¹Periodontology Department, The Boston University Institute for Dental Research and Education, PO Box 505097, Dubai Healthcare City, Dubai, United Arab Emirates. kinaia@perio.org

Dental Clinics of North America

|July 28, 2012

Summary

Periodontal and endodontic diseases cause tissue loss. Regenerative therapies using grafts, growth factors, and stem cells show promise but complete tissue restoration remains a challenge.

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Area of Science:

Dentistry
Regenerative Medicine

Background:

Periodontal and endodontic diseases involve inflammatory responses leading to significant tissue loss.
Restoring lost periodontal and pulpal structures to full vitality and function is a primary goal in dental regenerative therapies.

Purpose of the Study:

To provide a chronological review of materials and methods used in periodontal and endodontic regeneration.
To highlight the clinical successes and limitations of current regenerative approaches.
To discuss future directions in the field of dental tissue regeneration.

Main Methods:

Review of existing literature on periodontal and endodontic regenerative materials and treatments.
Chronological analysis of therapeutic approaches including bone grafts, guided tissue regeneration, enamel matrix derivatives, growth factors, and stem cells.
Evaluation of clinical outcomes, successes, and shortcomings of reviewed methods.

Main Results:

Various regenerative materials and treatments have been employed with varying degrees of clinical success.
Current methods, while effective, have not yet achieved complete biological tissue regeneration.
A historical perspective on the evolution of regenerative therapies in periodontics and endodontics.

Conclusions:

Despite advancements, achieving complete periodontal and endodontic tissue regeneration remains an ongoing challenge.
Continued research into novel materials and treatment strategies is essential for future progress.
The review identifies key areas for future research and development in regenerative dentistry.