Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Source And Potency Of Stem Cells

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...

Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

Stem Cell Culture

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.

Adult Stem Cells

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Redefining the Evolution of Pulpal Pathology: Inflammasomes as Central Integrative Hubs and Biological Switches Governing the Transition From Reversible to Irreversible Pulpal Inflammation Beyond Symptom-Based Classification.

International endodontic journal·2026

Same author

From Evidence-based Endodontics to Generative AI: A Comparative Study of 11 Large Language Models.

Journal of endodontics·2026

Same author

Outcome assessment of orthodontic clear aligner vs fixed appliance treatment in a teenage population with mild malocclusions.

The Angle orthodontist·2020

Same author

Insights Into the January 2021 Issue of the JOE.

Journal of endodontics·2020

Same author

Insights into the December 2020 Issue of the JOE.

Journal of endodontics·2020

Same author

Insights into the November 2020 issue of the JOE.

Journal of endodontics·2020

Search research articles

Related Experiment Video

Updated: May 20, 2026

Isolation, Culture, and Characterization of Dental Pulp Stem Cells from Human Deciduous and Permanent Teeth

Isolation, Culture, and Characterization of Dental Pulp Stem Cells from Human Deciduous and Permanent Teeth

Published on: May 17, 2024

Dental stem cells and their sources.

Christine M Sedgley¹, Tatiana M Botero

¹Department of Endodontology, School of Dentistry, Oregon Health and Science University, 611 Southwest Campus Drive, Portland, OR 97239, USA. sedgley@ohsu.edu

Dental Clinics of North America

|July 28, 2012

Summary

This summary is machine-generated.

Dental stem cells (DSCs) from teeth offer a promising alternative to bone marrow stem cells. These cells can self-renew and differentiate into various tissues, showing potential in regenerative medicine.

More Related Videos

Primary Culture of Dental Pulp Stem Cells

Primary Culture of Dental Pulp Stem Cells

Published on: May 5, 2023

Isolation, Characterization and MicroRNA-based Genetic Modification of Human Dental Follicle Stem Cells

Isolation, Characterization and MicroRNA-based Genetic Modification of Human Dental Follicle Stem Cells

Published on: November 16, 2018

Related Experiment Videos

Last Updated: May 20, 2026

Isolation, Culture, and Characterization of Dental Pulp Stem Cells from Human Deciduous and Permanent Teeth

Isolation, Culture, and Characterization of Dental Pulp Stem Cells from Human Deciduous and Permanent Teeth

Published on: May 17, 2024

Primary Culture of Dental Pulp Stem Cells

Primary Culture of Dental Pulp Stem Cells

Published on: May 5, 2023

Isolation, Characterization and MicroRNA-based Genetic Modification of Human Dental Follicle Stem Cells

Isolation, Characterization and MicroRNA-based Genetic Modification of Human Dental Follicle Stem Cells

Published on: November 16, 2018

Area of Science:

Biomedical Engineering
Stem Cell Biology
Regenerative Medicine

Background:

Mesenchymal stem cells (MSCs) are crucial for tissue regeneration.
Bone marrow-derived MSCs are traditionally used but invasive to obtain.
Dental tissues present an accessible source of stem cells.

Purpose of the Study:

To review the potential of human dental stem cells (DSCs) as an alternative to bone marrow MSCs.
To highlight the characteristics and differentiation capabilities of various DSC populations.

Main Methods:

Literature review of studies isolating and characterizing DSCs.
Analysis of in vitro and animal studies demonstrating DSC differentiation.
Identification of common properties of DSCs.

Main Results:

Several types of DSCs have been identified, including dental pulp stem cells, stem cells from exfoliated deciduous teeth, stem cells from apical papilla, periodontal ligament stem cells, and dental follicle progenitor cells.
DSCs exhibit self-renewal capacity.
DSCs can differentiate into multiple lineages, including osseous, odontogenic, adipose, endothelial, and neural-like tissues.

Conclusions:

DSCs represent an accessible and viable source of stem cells for regenerative applications.
The multipotency of DSCs supports their potential use in diverse therapeutic strategies.
Further research into DSCs can advance regenerative medicine and reduce reliance on bone marrow harvesting.